The Celli Lab
University of Massachussetts Boston
Department of Physics








For an up-to-date listing and citations:


V Karimnia, I Rizvi, FJ Slack, JP Celli. Photodestruction of Stromal Fibroblasts Enhances Tumor Response to PDT in 3D Pancreatic Cancer Coculture Models. Photochemistry and Photobiology 97 (2), 416-426


S Khan, MAB Hussain, AP Khan, H Liu, S Siddiqui, S Mallidi, PL Alacron, L Daly, G Rudd, F Cuckov, C Hopper, SG Bown, K Akhtar, SA Hasan, SA Siddiqui, T Hasan, JP Celli. Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer. Journal of biomedical optics 25 (6), 063813


KS Samkoe, JP Celli, TC Zhu. Special Section Guest Editorial: Photodynamic Therapy. Journal of biomedical optics 25 (6), 063801


S Nath, M Pigula, AP Khan, W Hanna, MK Ruhi, FM Dehkordy, K Pushpavanam, K Rege, K Moore, Y Tsujita, C Conrad, F Inci, MG Del Carmen, W Franco, JP Celli, U Demirci, T Hasan, H-C Huang, I Rizvi. Flow-induced Shear Stress Confers Resistance to Carboplatin in an Adherent Three-Dimensional Model for Ovarian Cancer: A Role for EGFR-Targeted Photoimmunotherapy Informed by Physical Stress. Journal of clinical medicine 9 (4), 924


AJ Sorrin, M Kemal Ruhi, NA Ferlic, V Karimnia, WJ Polacheck, JP Celli, HC Huang, Imran Rizvi. Photodynamic therapy and the biophysics of the tumor microenvironment. Photochemistry and photobiology 96 (2), 232-259


R Jafari, GM Cramer, JP Celli. Modulation of Extracellular Matrix Rigidity Via Riboflavinmediated Photocrosslinking Regulates Invasive Motility and Treatment Response in a 3D Pancreatic Tumor Model. Photochemistry and photobiology 96 (2), 365-372



H Liu, L Daly, G Rudd, AP Khan, S Mallidi, Y Liu, F Cuckov, T Hasan, JP Celli. Development and evaluation of a lowcost, portable, LEDbased device for PDT treatment of earlystage oral cancer in resourcelimited settings. Lasers in surgery and medicine 51 (4), 345-351.


S Mallidi, AP Khan, H Liu, L Daly, G Rudd, P Leon, S Khan, BMA Hussain,SA Hasan, SA Siddique, K Akhtar, M August, M Troulis, F Cuckov, JP Celli, T Hasan. Platform for ergonomic intraoral photodynamic therapy using low-cost, modular 3D-printed components: design, comfort and clinical evaluation. Scientific reports 9 (1), 1-8


N Kumar, GM Cramer, SA Zamani Dahaj, B Sundaram, JP Celli, RV Kulkarni.

Stochastic modeling of phenotypic switching and chemoresistance in cancer cell populations Scientific Reports 10845.


C Rodriguez-Quijada, H de Puig, M Sanchez-Purra, C Yelleswarapu, JJ Evans, JP Celli, K Hamad-Schifferli. Protease Degradation of Protein Coronas and Its Impact on Cancer Cells and Drug Payload Release. ACS applied materials & interfaces 11 (16), 14588-14596


P Leon, G Rudd, L Daly, H Liu, JP Celli, T Hasan, F Cuckov. Development of a portable intraoral camera and a smartphone application for oral cancer PDT treatment guidance and monitoring. 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS), 1-4


H Chen, TH Yeh, J He, C Zhang, R Abbel, MR Hamblin, Y Huang, RJ Lanzafame, I Stadler, J Celli, SW Liu, ST Wu, Y Dong. Flexible quantum dot lightemitting devices for targeted photomedical applications. Journal of the Society for Information Display 26 (5), 296-303

M Broekgaarden, I Rizvi, AL Bulin, L Petrovic, R Goldschmidt, I Massodi, JP Celli, T Hasan. Neoadjuvant photodynamic therapy augments immediate and prolonged oxaliplatin efficacy in metastatic pancreatic cancer organoids. Oncotarget 9 (16), 13009


DP Jones, W Hanna, GM Cramer, JP Celli In situ measurement of ECM rheology and microheterogeneity in embedded and overlaid 3D pancreatic tumor stroma co-cultures via passive particle tracking


Journal of Innovative Optical Health Sciences, 1742003Quantum dot light emitting devices for photomedical applications

H Chen, J He, R Lanzafame, I Stadler, HE Hamidi, H Liu, J Celli, MR Hamblin, Y Huang, E Oakley, G Shafirstein, HK Chung, ST Wu, Y Dong

Journal of the Society for Information Display 25 (3), 177-184


JP Celli, MD Anderson. Cancer Biophysics. Elsevier Reference Module Series (2017).

L Daly, G Rudd, H Liu, P Leon, J Celli, F Čučkov. Embedded system for a battery-operated LED-based photodynamic therapy device for treatment of early-stage oral cancers in resource-limited settings.  2017 2nd International Conference on Bio-engineering for Smart Technologies (BioSMART) (2017) 1-4


Cramer GM, Jones DP, El Hamidi H, Celli JP. ECM Composition and Rheology Regulate Growth, Motility and Response to Photodynamic Therapy in 3D Models of Pancreatic Ductal Adenocarcinoma. Molecular Cancer Research (2017) 15(1) 1-25


Ouyang Z, Mainali M, Sinha N, Strack G, Altundal Y, Hao Y, Winningham T, Sajo E, Celli JP, Ngwa W. Potential of using cerium oxide nanoparticles for protecting healthy tissue during Accelerated Partial Breast Irradiation. Physica Medica (2016) 32(4), 631-635.

Liu H, and Celli JP. “Looking out the optical window: Physical principles and instrumentation for imaging in photodynamic therapy.” in Imaging and Photodynamic Therapy by Taylor and Francis. In Press

Cramer GM, El Hamidi H, Jafari S, Jones DP, Celli JP. Extracellular matrix composition and rigidity regulate invasive behavior and response to PDT in 3D pancreatic tumor models. Proc SPIE 2016, 96940J-96940J-7.

Liu H, Rudd G, Daly L, Hempstead J, Liu Y, Khan AP, Mallidi S, Thomas R, Rizvi I, Arnason S, Cuckov F, Hasan T, Celli JP. Development of low-cost devices for image-guided photodynamic therapy treatment of oral cancer in global health settings Proc SPIE 2016, 96940C-96940C-6.


Hempstead J, Jones DP, Ziouche A, Cramer G, Rizvi I, Arnason S, Hasan T, Celli JP.  Low-cost photodynamic therapy devices for global health settings: Characterization of battery-powered LED performance and smartphone imaging in 3D tumor models. Scientific Reports (2015) 5:10093.

Mallidi S, Mai Z, Rizvi I, Hempstead J, Arnason S, Celli JP, Hasan T. In vivo evaluation of battery-operated LED based photodynamic therapy efficacy using tumor volume and biomarker expression as endpoints. Journal of Biomedical Optics (2015) 20 (4), 048003-048003

Jones DP, Hanna W, Celli JP. Mapping dynamic mechanical remodeling in 3D tumor models via particle tracking microrheology. Proc SPIE 2015, 93270L-93270L-5.

Rizvi I, Gudejko H, Briars E, Khan S, Chiang C, El-Hamidi H, Celli JP, Hasan T. “3D Cancer Models on Hydrogels” in  Gels Handbook Volume 1: Fundamentals, Properties and Applications. Editor S. Majd. World Scientific Publishing 2015


Li Y, Petrovic L, La J, Celli JP, Yelleswarapu CS. Digital holographic microscopy for longitudinal volumetric imaging of growth and treatment response in 3D tumor models. Journal of Biomedical Optics (2014) 19 (11), 116001.

Jones DP, Hanna W, El-Hamidi H, Celli JP. Longitudinal quantification of local mechanical changes in 3D tumor models using particle-tracking microrheology.  J. Vis. Exp. (88), e51302, doi:10.3791/51302 (2014).

Li Y, Petrovic L, Celli JP*, Yelleswarapu CS*. Digital Holographic Microscopy (DHM) for imaging growth and treatment response in 3D tumor models. Proc SPIE 2014, 8957-3.

Celli JP, Rizvi I, Blanden AR, Massodi I, Glidden MD, Pogue BW, Hasan T. An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models. Scientific Reports (2014);4:3751.


Anbil S, Rizvi I, Celli JP, Alagic N, Pogue BW, Hasan T. Impact of treatment response metrics on photodynamic therapy planning and outcomes in a three-dimensional model of ovarian cancer. Journal of Biomedical Optics (2013) 18(9), 098004. 

Celli JP, Petrovic L, Massodi I, Rizvi I, Hasan T. Overcoming therapeutic resistance in pancreatic cancer is not a simple mix of PDT and chemotherapy: Evaluation of PDT-chemotherapy combinations in 3D tumor models. Proc SPIE 2013, 8568-0R

Bansil R, Celli JP, Hardcastle JM, Turner BS. The influence of mucus microstructure and rheology in H. pylori infection. Frontiers in Immunology (2013); 4: 310, doi: 10.3389/fimmu.2013.00310,

Rizvi I, Gurkan UA, Tasoglu S, Alagic N, Celli JP, Mensah LB, Mai Z, Demirci U, Hasan T. Flow Induces a Motile and Aggressive Phenotype in 3D Ovarian Cancer Nodules via Increased EMT, Activated EGFR and Decreased E-Cadherin. Proceedings of the National Academy of Science of the United States of America (2013); 110 (22) E1974–E1983

Rizvi I, Anbil SA, Alagic N, Celli JP, Zheng LZ, Palanisami A, Glidden MD, Pogue BW, Hasan T. PDT Dose Parameters Impact Tumoricidal Durability and Cell Death Pathways in a 3D Ovarian Cancer Model. Photochemistry and Photobiology (2013); 89(4) 942-952.


Glidden MD, Celli JP, Massodi I, Hasan T. Image-based quantification of photosensitizer uptake, localization and photobleaching in a 3D tumor model for optimization of PDT parameters. Theranostics (2012) 2(9), 827-839

Celli JP. Stromal interactions as regulators of tumor growth and therapeutic response: A potential target for photodynamic therapy? Israel Journal of Chemistry (2012) 52, 757-766

Glidden MD, Massodi I, Rizvi I, Celli JP*, Hasan T. Probing tumor-stroma interactions and response to photodynamic therapy in a 3D pancreatic cancer-fibroblast co-culture model. Proc SPIE 2012, 8210-05 *Corresponding Author


Xu F*, Celli JP*, Rizvi I, Moon S, Hasan T, Demirci U. A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform.  Biotechnology Journal (2011) Vol 6 doi: 10.1002/biot.201000340 *Equal Contribution

Celli JP, Solban N, Liang A, Pereira SP, Hasan T. Verteporfin-based photodynamic therapy overcomes gemcitabine insensitivity in a panel of pancreatic cancer cell lines. Lasers in Surgery and Medicine (2011); 43 (7), 565–574.

Evans CL, Abu-Yousif AO, Park YJ, Klein OJ, Celli JP, Rizvi I, Zheng X, Hasan T. Killing Hypoxic Cell  Populations in a 3D Tumor Model with EtNBS-PDT. PLoS One (2011); 6(8) e23434.

Celli JP, Rizvi I, Blanden A, Abu-Yousif AO, Spring B, Hasan T. Biologically-relevant 3D tumor arrays: Imaging-based methods for quantification of reproducible growth and analysis of treatment response. Proc SPIE  2011, 7886-08.

Rizvi, I.; Celli JP, Xu F, Evans CL, Abu-Yousif AO, Muzikansky A, Elrington SA, Pogue BW, Finkelstein DM, Demirci U, Hasan, T, Biologically-relevant 3D tumor arrays: Treatment response and the importance of stromal partners. Proc SPIE  2011, 7886-09.

Celli, J.P.; Rizvi, I.; Blanden, A.; Evans, C.; Abu-Yousif, A.; Spring, B.; Muzikansky, A.; Pogue, B.; Finkelstein, D.; Hasan, T., Imaging Enabled Platforms for Development of Therapeutics. Proc SPIE 2011, 7910-1.


Celli JP, Spring BQ, Rizvi I, Evans CL, Samkoe KS, Verma S, Pogue BW, Hasan T. Imaging and Photodynamic Therapy: Mechanisms, Monitoring and Optimization. Chemical Reviews (2010); Vol. 110 (5), 2795–2838. PMID: 20353192, PMCID: PMC2896821

Celli JP, Rizvi I, Evans CL, Abu-Yousif AO, Hasan T. Quantitative imaging reveals heterogeneous growth dynamics and treatment-dependent residual tumor distributions in a 3D model for ovarian cancer. Journal of Biomedical Optics (2010), Vol 15(5), 051603. doi: 10.1117/1.3483903

Rahmanzadeh R, Rai P, Celli JP, Rizvi I, Baron-Luehr B, Gerdes J, Hasan T. Ki-67 as a molecular target for therapy in an in vitro 3D model for ovarian cancer. Cancer Research (2010). Vol 70(22), 9234-42. doi: 10.1158/0008-5472.CAN-10-1190

Rizvi I, Celli JP, Evans CL, Abu-Yousif AO, Alona Muzikansky, Brian Pogue, Dianne Finkelstein, Hasan T. Carboplatin efficacy enhanced synergistically by Photodynamic Therapy in a 3D model of micrometastatic ovarian cancer. Cancer Research (2010) Vol 70(22), 9319-28.doi: 10.1158/0008-5472.CAN-10-1783.

Celli, J. P.; Rizvi, I.; Evans, C. L.; Abu-Yousif, A. O.; Hasan, T., 3D ovarian cancer models: imaging and therapeutic combinations. Proc. SPIE 2010, 7551-17. DOI: 10.1117/12.843279


Celli JP, Turner BS, Afdhal NH, Keates S, Ghiran I, Kelly C, Ewoldt RH, McKinley GH, So P, Erramilli S, Bansil R. Helicobacter pylori moves through mucus by reducing mucin viscoelasticity. Proceedings of the National Academy of Sciences of the United States of America (2009); Vol 106(34), 14321-14326. PMID: 19706518, PMCID: PMC2732822 *The discovery described in this article was featured as a Research Highlight in Nature Reviews Microbiology (2009); Volume 7, No. 10, 689.

Zhong W*, Celli JP*, Rizvi I, Mai Z, Spring B, Yun SH, Hasan T. In vivo high resolution fluorescence microendoscopy for ovarian cancer detection and treatment monitoring. British Journal of Cancer (2009). Vol 101, 2015-2022. PMID: 19920823, PMCID: PMC2795438  *Equal Contribution

Abu-Yousif AO, Rizvi I, Evans CL, Celli JP, Hasan T. PuraMatrix Encapsulation of Cancer Cells. Journal of Visualized Experiments (2009). 34., PMID: 20019656

Evans CL, Rizvi I, Celli JP, Abu-Yousif AO, de Boer JF, Hasan T. Visualizing photodynamic therapy response with time-lapse OCT in an in vitro model of metastatic ovarian cancer. Proc. SPIE Vol. 7551, Paper 7551-18 DOI: 10.1117/12.843271

Spring BQ, Celli JP, Evans CL, Zhong W, Rizvi I, Mai Z, Mertz J, Yun SH, and Hasan T. Intravital fiber-optic fluorescence imaging for monitoring ovarian carcinoma progression and treatment response. Proc. SPIE, Vol. 7380, 73800L (2009); doi:10.1117/12.828206

2007 and Earlier:

Celli JP, Turner BS, Afdhal NH, Ewoldt RH, McKinley GH, Bansil R, Erramilli S. Rheology of Gastric Mucin Exhibits a pH-Dependent Sol-Gel Transition. Biomacromolecules, (2007); 8(5), 1580-86. PMID: 17402780

Hicks RS, Decowski P, Arroyo C, Breuer M, Celli JP, Chudakov E, Kumar KS, Olson M, Peterson GA, Pope K, Ricci J, Savage J and Souder PA. Flux profile scanners for scattered high-energy electrons. Nuclear Instruments and Methods in Physics Research Section A (2005); 553(3), 470-482.

Celli JP, Gregor BF, Turner BS, Afdhal NH, Bansil R, Erramilli S.  Viscoelastic Properties and Dynamics of Porcine Gastric Mucin, Biomacromolecules (2005); 6(3) 1329-33. PMID: 15877349

Bansil R, Celli JP, Chasan B, Erramilli S, Hong Z, Afdhal NH, Bhaskar KR, Turner BS. pH-dependent Gelation of Gastric Mucin, Mat. Res. Soc. (2005); Symp J Proc. Vol. 897E.